Ciaran Kohli-Lynch, PhD
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University
Chicago, Illinois, United States
Ricky Hill, PhD
Northwestern University
Chicago, Illinois, United States
Kristina M. Diaz, MSN RN CNL
Department of Surgery, Robert J. Havey, MD Institute for Global Health, Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
Funmilola O. Wuraola, MBBS FWACS ChM
Obafemi Awolowo University Teaching Hospitals Complex
Ife-Ife, Osun, Nigeria
Chinenye Iwuji, BM BSc MSc PhD (she/her/hers)
Head of Medical Oncology
Department of Oncology, Lakeshore Cancer Center
Lagos, Lagos, Nigeria
Oge Ilegbune, MBBS
Lakeshore Cancer Center
Lagos, Lagos, Nigeria
Chukumere Nwogu, MD, PhD
Professor of Surgery
Lakeshore Cancer Center; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center
New York, New York, United States
Bindiya Chugani, MSc
Lakeshore Cancer Center
Lagos, Lagos, Nigeria
Lisa Hirshchhorn, MD, MPH
Department of Medical Social Sciences and Robert Havey Institute for Global Health, Feinberg School of Medicine, Northwestern University
Chicago, Illinois, United States
Dan Sherman, MA, LPC
The NaVectis Group
Grand Rapids, Michigan, United States
Clara Lambert, BBA, CPH
TailorMed
Chicago, Illinois, United States
Andrei Adin-Cristian, PhD
Professor
Department of Preventive Medicine, Division of Biostatistics and Informatics, Northwestern University, Feinberg School of Medicine
Chicago, Illinois, United States
T. Peter Kingham, MD
Professor
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Ruohui Chen, PhD
Department of Preventive Medicine, Division of Biostatistics and Informatics, Northwestern University, Feinberg School of Medicine
Chicago, Illinois, United States
Juliet S. Lumati, MD MPH
Assistant Professor| Department of Surgery| Division of Surgical Oncology
Department of Surgery, Robert J. Havey, MD Institute for Global Health, Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
Segun Afolaranmi, MD, MSc
Resident
Mayo Clinic
Rochester, Minnesota, United States
Median OOP costs decreased more rapidly among FNP participants than controls ($20 [₦30,000] vs $40 [₦60,000] at six months; $23 [₦30,000] reduction). The routine-care (RC) arm incurred approximately twice the median OOP cost of the FNP arm (Figure 1). FNP participants were less likely to experience FC than controls (OR 0.10; 95% CI 0.01–0.91; p = 0.04). No FNP participants discontinued treatment due to cost, compared with 15% of controls (p = 0.05).
At the program level, total implementation—including navigator salaries and coaching—averaged $19,000 [₦29 million] over the 15-month period (≈ $9,500 per navigator), corresponding to an average cost of $214 [₦320,000] per patient. Downstream benefits yielded mean savings of $300 [₦456,000] per patient, producing a net benefit of $8,000 [₦12 million] and an ROI of 40%, with greater efficiency observed at the public than the private sites.
Conclusions:
The FNP represents a low-cost, feasible, and economically favorable strategy to reduce FT and improve TA to cancer care in LMICs. ROI estimates indicate modest short-term returns with a strong trajectory toward long-term value. These results support integrating FNPs into national cancer-control strategies to enhance financial protection, treatment continuity, and equity in resource-limited settings.